Other languages abstract :
In this scientific piece of research work, chlorpromazine CPZ (a psychaity drug) was determined spectrophotometrically using micro amount of reactant.
In addition to micro amount of spectrophotometric reagent (400 ^l).
Various oxidizing agents were tested, including periodate, iodate, bromate, ferric nitrate, ferri cynate and persulphate.
Oxidation reactions of the active ingradient (2,10-disubstituted phenothiazine) was used for the determination of CPZ in the presence of ferric nitrate.
Detailed study of all chemical and physical parameters were studied.
Ion-exchange columns were used to overcome the interfering ions.
Percentage linearity was 99.86 for 0.04-8 mM CPZ, L.O.D.
was 1x106M.
Repeatabilety was better than 1.5%.
The established results were followed to determine in some drugs.
Keywords :
طريقة طيفية مباشرة , تقدير الكلوربرومازين , المستحضرات الصيدلانية , مبادلات ايونية , لازالة المتداخلات
