Author/Authors :
Shafiee, Mostafa Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Hafez Ghoran, Salar Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Bordbar, Sadegh Department of Chemical Engineering - Isfahan University of Technology - Isfahan, Iran , Gholami, Mina Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Naderian, Moslem Department of Pharmacognosy - School of Pharmacy - Shiraz University of Medical Sciences - Shiraz, Iran , Dehghani, Fatemeh Sadat Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran , Amani, Ali Mohammad Department of Medical Nanotechnology - School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz, Iran
Abstract :
The use of core-shell nanoparticles as controlled drug delivery vehicles has
proven successful, yet their production and application require costly and
toxic chemicals. We hereby use a natural glycosylated flavonoid (rutin)
for synthesis of a nanocarrier for doxorubicin delivery. For this target,
a convenient two-step synthesis was processed including a synthesis of
bio-zinc ferrite nanoparticles without N2 gas and chitosan coating (CS;
bio-zincferrite@chitosan). The as-synthesized magnetic nanogel was
characterized using scanning electron microscopy (SEM), transmission
electron microscopy (TEM), Fourier transformed infrared (FT-IR)
spectroscopy, and electro-analytical methods including cyclic voltammetry
and electrochemical impedance spectroscopies. The collapse/swell potential
of the coated CS layers of the bio-NPs were found to be responsible for
the observed pH dependence of doxorubicin delivery. Results exhibited
the drug release of bio-nanogel can be induced at pH ranging from 6 to
7. Therefore, capacity and efficiency parameters of the anti-cancer drug
onto the NPs were obtained as equal to 43.5% and 78.6%. The present work
provides a simple method to fabricate smart pH-responsive nanogel for
cancer therapy.
Keywords :
As-synthesized ZnFe2O4 NPs , Chitosan , Doxorubicin , Drug delivery , Ruta graveolens L , Rutin
