Title of article
Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients
Author/Authors
Al-Shammaree, Shatha Abd AL- Wadood University of Baghdad - College of Science - Depts chemistry, Iraq
From page
1166
To page
1173
Abstract
Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy. The results indicated that ADA specific activity increased significantly (P 0.05), while 5´-NT and AMPDA specific activity decreased significantly (P 0.05) in ovarian cancer patients before surgery in comparison with those of their corresponding control women and benign tumors groups. When the activities of these enzymes were measured after chemotherapy, a significant decrease (P 0.05) in ADA activity, and a significant increase (P 0.05) in 5´- NT and AMPDA activities were found in comparison with those before surgery
Keywords
Adenosine deaminase (ADA) , 5´ , Nucleotidase (5´ , NT) , AMP – deaminase (AMPDA) , ovarian cancer , chemotherapy
Journal title
Baghdad Science Journal
Journal title
Baghdad Science Journal
Record number
2688753
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