Title of article :
Spectrofluorimetric method for the determination of glibenclamide in pharmaceutical formulations
Author/Authors :
Khalaf, Karim D. University of Baghdad - College of Science for Women - Department of Chemistry, Iraq , Hassen, Perween A. Ministry of Education - Directorate of Education, Iraq
Abstract :
A sensitive spectrofluorimetric method for the determination of glibenclamide in its tablet formulations has been proposed. The method is based on the dissolving of glibenclamide in absolute ethanol and measuring the native fluorescence at 354 nm after excitation at 302 nm. Beers law is obeyed in the concentration of 1.4 to 10 μg.ml-1 of glibenclamide with a limit of detection (LD) of 0.067 μg.ml-1 and a standard deviation of 0.614. The range percent recoveries (N=3) is 94 - 103.
Keywords :
Glibenclamide , spectrofluorimetric.
Journal title :
Baghdad Science Journal
Journal title :
Baghdad Science Journal
