Title of article :
Chloroquine-induced Acute Dystonic Reactions after a Standard Therapeutic Dose for Uncomplicated Malaria
Author/Authors :
Busari, Olusegun A. Federal Medical Centre - Department of Internal Medicine, Nigeria , Fadare, Joseph Federal Medical Centre - Department of Internal Medicine, Nigeria , Agboola, Segun Federal Medical Centre - Departments of Family Medicine, Nigeria , Gabriel, Olusegun Federal Medical Centre - Departments of Family Medicine, Nigeria , Elegbede, Olayide Federal Medical Centre - Departments of Family Medicine, Nigeria , Oladosu, Yusuf Federal Medical Centre - Departments of Family Medicine, Nigeria
Abstract :
Acute dystonic reactions (ADR) are extrapyramidal effects that usually occur after the initiation of awide variety of drugs or triggering factors besides neuroleptics. We report the case of a 54-year-old man who was admitted with an approximately 10-hour history of muscle twitching around the eyes, face and neck after he took the first dose of oral chloroquine phosphate (1 g [600 mg base]) prescribed for uncomplicated malaria. He was given intravenous diazepam (10 mg statum) followed by 10 mg of oral diazepam 3 times a day. The symptoms improved within 30 minutes of treatment, and he was discharged 14 hours later after a complete recovery.
Keywords :
Dystonia , Reactions, acute , Malaria , Chloroquine , Administration, Oral , Case Report , Nigeria
Journal title :
Sultan Qaboos University Medical Journal (SQUMJ)
Journal title :
Sultan Qaboos University Medical Journal (SQUMJ)
