Title of article :
MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19
Author/Authors :
Pimenta, Ruan Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Viana, Nayara Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Santos, Gabriel A dos Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Candido, Patricia Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Guimaraes, Vanessa R Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Romao, Poliana Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Silva, Iran A Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Camargo, Juliana A de Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Hatanaka, Dina M Moriah Hospital - São Paulo, SP, Brazil , Queiro, Paula G S Moriah Hospital - São Paulo, SP, Brazil , Teruya, Alexandre Moriah Hospital - São Paulo, SP, Brazil , Echenique, Leandro Moriah Hospital - São Paulo, SP, Brazil , Besen, Bruno A M P Instituto Central - Hospital das Clinicas HCFMUSP - Faculdade de Medicina - Universidade de SaoPaulo, Sao Paulo, SP, Brazil , Leite, Katia R M Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Srougi, Victor Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Srougi, Miguel Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil , Reis,Sabrina T Laboratory of Medical Investigation (LIM55) - Urology Department -Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
Pages :
7
From page :
141
To page :
147
Abstract :
COVID-19 represents a public health emergency, whose mechanism of which is not fully understood. It is speculated that microRNAs may play a crucial role in host cells after infection by SARS-CoV-2. Thus, our study aimed to analyze the expression of miR-200c-3p in saliva samples from patients with COVID-19. One handred eleven samples from patients with COVID-19 were divided into 4 groups. Group I: 39 patients negative for Covid-19; Group II: 37 positive and symptomatic patients, with no indication of hospitalization; Group III: 21 patients with respiratory disorders (hospitalized); Group IV: 14 patients with severe conditions (oxygen therapy). The expression levels of miR-200c-3p were determined using qPCR. We found greater expression of miR-200c-3p in patients in group IV (p <0.0001), and also verified that patients aged ≥42 years had a higher expression of this miR (p =0.013). Logistic regression analysis revealed that the expression of miR-200c-3p and systemic arterial hypertension are factors independently associated with patients in group IV (p <0.0001). Our results suggest that miR-200c-3p is a predictor of severity independent of COVID-19 risk factors, which could represent a way of screening patients affected by SARS-CoV-2.
Keywords :
microRNA , COVID-19 , SARs-CoV-2 , Biomarkers
Journal title :
Molecular Biology Research Communications
Serial Year :
2021
Record number :
2691219
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2691219
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