Synthesis and Characterization of Some New Azo Dyes Derivatives Via Chalcone and Study Some of Their Biological Activity

This work includes synthesis of new six membered heterocyclic rings witheffective amino group using the reaction of benzylideneacetophenone (chalcone) (1)with thiourea or urea in alcoholic basic medium to form: 1,3-thiazen-2-amine (2), and1,3-oxazin-2-amine (8) respectively.The diazotization reaction was carried out with sodium nitrite in presence ofhydrochloric acid to form diazonium salts which suffered coupling reaction withnaphthols and phenols in the presence of sodium hydroxide to form colored azo dyes(4-7, and 10-13).o-methylation reaction of compounds (7) and (10) yielded : 1,3-thiazin -2-yldiazenyl(14), and 1,3-oxazin-2-yl-diazenyl (15) respectively.The new compounds were characterized using various physical techniques like: UVVis.,FT-IR, and 1HNMR spectra. Some new compounds were tested against bacteria.