Letters to the Editors: Two-in-One: single coronary ostium and mitral valve prolapsus in a young female with Alport syndrome

A 23-year-old female with chronic renal failure because of Alport syndrome (AS) consulted for cardiac evaluation before renal transplantation. She described dyspnea with minimal effort and atypical chest pain. Past medical history includes adulthood onset, autosomal recessive type AS, due to a missense mutation in the COL4A3 gene, with development of severe renal insufficiency, hypertension, anterior lenticonus and mild sensorineural deafness for 4 years. She was taking carvedilol and amlodipine for hypertension. Examination showed arrhythmic pulse, apical 3/6 systolic murmur, other systems and biochemical parameters were unremarkable except renal function tests. Electrocardiogram revealed atrial fibrillation.