Strict patient selection for renal sympathetic denervation may yield to more favorable results

We read with a great interest the article by Drexel et al. (1) entitled as Renal denervation-Review that published recently in this journal. Renal sympathetic denervation (RSD) opened a new era in the treatment of resistant hypertension (HT). However, there is a still large arguments about the efficacy of RSD in the long term period (2, 3). Some authors, proposed that, the effect is similar to placebo or Harthowm effect, whereas others defend the initial reported results showing the favorable effect. Drexel et al. (1) clearly demonstrated the pathophysiologic mechanism of RDS and Simpilicity-1 and Simplicity-2 trials.