Author`s Reply:Strict patient selection for renal sympathetic denervation may yield to more favorable results

Thank you for the interest in our recent review article published in March issue of The Anatolian Journal of Cardiology 2014; 14: 186-91 (1). We are in agreement with the excellent comments stated. Though physiological experience in animal models and humans as outlined by us and prior human experience with surgical sympathectomy suggests a sound scientific basis for renal denervation, as demonstrated in the past on numerous occasions, physiological evidence does not uniformly translate into the expected clinical results. The reasons for an absence of the expected blood pressure response after renal denervation in Symplicity HTN-3 remain unclear.