Author/Authors :
Kayıkçıoğlu, Meral Ege University - Faculty of Medicine - Department of Cardiology, Turkey , Yavuzgil, Oğuz Ege University - Faculty of Medicine - Department of Cardiology, Turkey , Eroğlu, Zuhal Ege University - Faculty of Medicine - Department of Medical Biology, Turkey , Onay, Hüseyin Ege University - Faculty of Medicine - Department of Medical Genetics, Turkey , Ergenoğlu, Mete Ege University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , Can, Levent Ege University - Faculty of Medicine - Department of Cardiology, Turkey
Abstract :
We report two women presenting with myocardial infarction (MI) associated with pregnancy. Both had no known risk factors except late parental history of cardiovascular disease. Table 1 shows the diagnostic work-up. Genotype analysis (real-time online PCR technique) was performed for detection of inherited thrombophilia including mutations of prothrombin (G20210A), factor-V Leiden (G1691A), factor-V R2 (H1299R), factor-XIII (V34L), ss-fibrinogen (G455A), and MTHFR (C677T and A1298C). Both patients were heterozygous for factor-V R2-mutation and homozygous for MTHFR (C677T).
