Author/Authors :
Radhakrishnan, Sivasankara The Royal Hospital - Departments of Gastroenterology, Oman , Upadhyay, Amal The Royal Hospital - Departments of Gastroenterology, Oman , Mohan, Nihar The Royal Hospital - Departments of Gastroenterology, Oman , Dhar, Anjan The Royal Hospital - Departments of Gastroenterology, Oman , Kaur Walia, Harbhajan The Royal Hospital - Departments of Gastroenterology, Oman , Zubaidi, Ghazi The Royal Hospital - Departments of Endocrinology, Oman
Abstract :
Objective: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient. Clinical Presentation and Intervention: A 50-year-old male with chronic hepatitis C received treatment with alfa-interferon and ribavirin for 52 weeks. He developed immune-mediated diabetes mellitus with low C-peptide and positive antiglutamic acid decarboxylase antibody after completion of therapy. The hepatitis C infection was eradicated, but he continued to be diabetic requiring insulin therapy during the follow-up. Conclusion: This report shows thatimmune-mediateddiabetes mellitus can occur as a late complication of alfa-interferon therapy.
Keywords :
Hepatitis C , Alfa , interferon , Immune , mediated diabetes mellitus
