Author/Authors :
Saraç, Fulden Ege University Hospital - Departments of Endocrinology and Metabolism, Turkey , Saydam, Güray Ege University Hospital - Departments of Hematology, Turkey , Sahin, Fahri Ege University Hospital - Departments of Hematology, Turkey , Öztekin, Kemal Ege University Hospital - Departments of Gynecology and Obstetrics, Turkey , Saygılı, Fusun Ege University Hospital - Departments of Endocrinology and Metabolism, Turkey , Tüzün, Mehmet Ege University Hospital - Departments of Endocrinology and Metabolism, Turkey , Yılmaz, Candeger Ege University Hospital - Departments of Endocrinology and Metabolism, Turkey
Abstract :
Objectives: The aim of this study was to evaluate measures of insulin resistance and platelet function in postmenopausal women with oral or transdermal hormone replacement therapy (HRT). Subjects and Methods: Eighty women divided into four groups of 20 each were enrolled in the study. Group 1: postmenopausal hysterectomized women who received only transdermal estradiol (13.9 mg/12.5 cm 2 ); group 2: women with intact uterus who were treated with estrogen-progestin combination (HRT); group 3: postmenopausal women who were treated with the selective estrogen receptor modulator tibolone, and group 4: women who were not taking any drugs for HRT were chosen as a control group (group 4). Results: In group 2, homeostasis model assessment of insulin resistance and fasting insulin levels were 2.90 8 0.37 and 9.3 8 3.0 U/ml, respectively, prior to administration of HRT. These levels were reduced to 1.91 8 0.41 (p = 0.001) and 7.1 8 2.7 U/ml (p = 0.002), respectively, after drug therapy. Mean levels of high-sensitivity C-reactive protein (hsCRP) were decreased with HRT only in group 2 (p = 0.002). No changes for biochemical and hematological pa- rameters were observed in the other groups. Platelet function tests showed no differences after HRT in any group. Conclusions: Estrogen-progestin combination HRT decreased measures of insulin resistance and hsCRP levels, but had no effect on platelet function tests in postmenopausal women.
