Granulomatous Inflammatory Response in a Case of Typhoid Fever

Objective: To present a case of culture-proven typhoid fever in which granulomas were demonstrated histologically in the ileum and mesenteric lymph nodes. Clinical Presentation and Intervention: A 47-year-old Pakistani man underwent emergency hemicolectomy for severe bleeding per rectum associated with diarrhea. Two large ulcers in the ileum, near the ileocolic junction, as well as mesenteric lymph nodes showed both necrotizing and non-necrotizing granulomas in addition to mixed inflammatory infiltrate on histology. Conclusion: Typhoid fever may be considered as one of the causes of the differential diagnoses of granulomatous inflammation of the small intestine.