Title of article
Role of Endorectal Magnetic Resonance Spectroscopic Imaging in Two Different Gleason Scores in Prostate Cancer
Author/Authors
Nagarajan, Rajakumar University of California, - Department of Radiological Sciences, USA , Margolis, Daniel University of California - Department of Radiological Sciences, USA , McClure, Tim University of California - Department of Radiological Sciences, USA , Raman, Steve University of California - Department of Radiological Sciences, USA , Thomas, M. Albert University of California - Department of Radiological Sciences, USA
From page
444
To page
448
Abstract
Objective: The major goal of the work was to record three-dimensional magnetic resonance spectroscopic imaging (MRSI) and to compare metabolite ratios between different Gleason scores (GS). Materials and Methods: MRSI localized by endorectal coil-acquired point-resolved spectroscopy was performed in 14 men with prostate cancer of GS 6 (n = 7) and 7 (n = 7) using a 1.5-tesla MRI scanner. Results: The ratio of (choline + creatine)/citrate was increased with an increase of GS, i.e. 0.590 ± 0.171 in the target lesion and 0.321 ± 0.157 in the contralateral region of patients with a GS of 6 as opposed to 1.082 ± 0.432 in the target lesion and 0.360 ± 0.243 in the contralateral region of patients with a GS of 7. Conclusion: Our pilot results demonstrated that MRSI was an additional biochemical tool which is complementary to the current imaging modalities for early diagnosis and therapeutic management of prostate cancer.
Keywords
Magnetic resonance spectroscopic imaging , Prostate cancer , Choline groups , Citrate , Creatine
Journal title
Medical Principles and Practice
Journal title
Medical Principles and Practice
Record number
2694774
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