Voltammetric and Spectroscopic Studies of Memantine Hydrochloride and its Transition Metal Complexes

In the present work, an electroanalytical technique (cyclic voltammetry) has been used to understand the electrochemical behavior of memantine hydrochloride and evaluate the overall response of the drug. The solution variables, such as the concentration of drug, and instrumental variables, such as scan rate, have been studied. It has been reported that functional groups in a parent drug could bind to transition metal ions; this led to facilitation of the drug delivery. In the present study, four transition metal complexes of Memantine hydrochloride including Fe, Cu, Ni, and Co complexes have been prepared. Characterization of transition metal complexes is carried out using IR and Atomic Absorption Spectroscopy. The redox properties are investigated using cyclic voltammetry.