Title of article
Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt
Author/Authors
Michel, Camilia Cairo University - Faculty of Pharmacy - Pharmacognosy Department, Egypt , El-sherei, Moshera Cairo University - Faculty of Pharmacy - Pharmacognosy Department, Egypt , Islam, Wafaa Cairo University - Faculty of Pharmacy - Pharmacognosy Department, Egypt , Sleem, Amani National Research Center - Pharmacology Department, Egypt , Ahmed, Shaimaa Cairo University - Faculty of Pharmacy - Pharmacognosy Department, Egypt
From page
1
To page
5
Abstract
A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and indomethacin (20 mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data.
Keywords
Pterocarpus dalbergioides , Stem bark , Antihyperglycemic , Anti , inflammatory
Journal title
Bulletin Of Faculty Of Pharmacy, Cairo University
Journal title
Bulletin Of Faculty Of Pharmacy, Cairo University
Record number
2696754
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