Title of article
Biotransformation of furanocoumarins by Cunninghamella elegans
Author/Authors
Attia, Ghada Ismail El-shahat Ali Tanta University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Abou-El-seoud, Kamillia A. Tanta University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Sayed Ibrahim, Abdel-Rahim Tanta University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt
From page
1
To page
4
Abstract
Biotransformation of Furanocoumarins; psoralen (1), bergapten (2), xanthotoxin (3) and imperatorin (4) was explored by Cunninghamella elegans NRRL 1392, revealing the metabolism of psoralen (1) and bergapten (2) into bergaptol (5), while xanthotoxin (3) and imperatorin (4) were converted into xanthotoxol (6). On the other hand unexpected conversion of xanthotoxin (3) into 3,4 dihydroxanthotoxin (7) occurred. The structure of the isolated pure metabolites was established using physical and spectroscopic techniques including, melting points, IR, ^1H NMR, ^13C NMR and mass spectroscopy.
Keywords
Biotransformation , Furanocoumarins , Cunninghamella elegans
Journal title
Bulletin Of Faculty Of Pharmacy, Cairo University
Journal title
Bulletin Of Faculty Of Pharmacy, Cairo University
Record number
2696811
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