Pyridoacridine alkaloids from deep-water marine organisms: Structural elucidation

Pyridoacridine alkaloids are unique marine nitrogenous compounds that represent a large family of alkaloids. They have been reported from different marine organisms like sponges, ascidians, anemones, prosobranch mollusk, and tunicates. Attention to pyridoacridines has risen because of their significant biological activities. The present review emphasizes mainly on pyridoacridines isolated marine organisms over the last years. Thus, the synthetic ones were not discussed. Herein, 95 pyridoacridine alkaloids isolated from marine organisms have been retrieved, in addition to their classification, isolation, sources, structures, molecular weight, physical, and (UV, IR, 1H and 13C NMR) spectral data.