Title of article
PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES
Author/Authors
Allam, Ahmed E. Al-Azhar University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , El-Shanawany, Mohamed A. Assiut University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Backheet, Enaam Y. Assiut University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Nafady, Alaa M. Al-Azhar University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt
From page
65
To page
76
Abstract
Five compounds (1-5) were firstly reported from the genus Centaurium family Gentianaceae. They were identified as Lisianthoside 1, Secoxyloganin 2, Secologanin dimethyl acetal 3, 1,8-Dihydroxy-3,5,6,7-tetramethoxyxanthone (Demethyleustomin) 4 and 1-Hydroxy- 3,5,6,7,8-pentamethoxyxanthone (Eustomin) 5. Structure elucidation was carried out with support of chemical and spectral analysis including 1D and 2D NMR experiments. All the isolated compounds showed promising antioxidant activity, liver microsomal enzymes reducing activity and CYP3A4 mRNA inhibition activity in the HepG2 cell line
Journal title
Bulletin Of Pharmaceutical Sciences, Assiut University
Journal title
Bulletin Of Pharmaceutical Sciences, Assiut University
Record number
2696926
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