Title of article :
Association between Chlamydia trachomatis Infection and Prostate Cancer: A Case-Control Study
Author/Authors :
Baseri ، Neda Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences , Eslami ، Gita Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences , Ghalavand ، Zohreh Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences , Zham ، Hanieh Cancer research center, Shohada-e Tajrish Hospital - Shahid Beheshti University of Medical Sciences , Azargashb ، Eznollah Department of community Medicine and Health - school of medicine - Shahid Beheshti University of Medical Sciences
From page :
319
To page :
326
Abstract :
Background: Evidence indicating the association of cancers and chronic inflammations is increasing. The importance of urinary tract and sexually transmitted infections (UTIs and STIs) in the development of prostate cancer is still unclear. Chlamydia trachomatis (C. trachomatis) is one of the most important causes of UTIs and STIs. Here, a case-control study was performed on the Iranian population to assess the association between C. trachomatis and prostate cancer (PC). Materials Methods: Paraffin-embedded prostate tissue specimens collected from 62 PC and 62 PBH (benign prostate hyperplasia) (as controls) patients were screened to detect C. trachomatis 16srRNA gene using nested polymerase chain reaction (nested PCR) method. A p-value .05 was interpreted as a remarkable difference using SPSS statistical software Ver. 16. Findings: There was a significant difference regarding the prevalence of C. trachomatis (p .001; OR=10.07; 95% CI [2.81-36.001]) between the PC (33.87%) and BPH (4.84%) samples. Furthermore, prostate-specific antigen (PSA) levels were statistically higher (p .05) in C. trachomatis-positive patients than in patients with negative C. trachomatis. Conclusion: It could be concluded that patients with a history of C. trachomatis infections are more likely to develope PC. Therefore, early diagnosis and treatment of C. trachomatis infection may help the prevention of PC. Moreover, nested PCR is a suitable method for C. trachomatis detection in paraffin-embedded prostate tissue specimens.
Keywords :
Prostate cancer , Chlamydia trachomatis , Benign prostatic hyperplasia , Sexually transmitted infections
Journal title :
Infection Epidemiology and Microbiology
Journal title :
Infection Epidemiology and Microbiology
Record number :
2697511
Link To Document :
بازگشت