Author/Authors :
Nasiri, M Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Kaeidi, Ayat Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Fatemi, Iman Research Center of Tropical and Infectious Diseases - Kerman University of Medical Sciences - Kerman, Iran , Azin, M Department of Physiology and Pharmacology - School of Medicine - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Bannazadeh, M Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Allahtavakoli, Mohammad Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Roohbakhsh, Ali Pharmaceutical Research Center - Pharmaceutical Technology Institute - Mashhad University of Medical Sciences - Mashhad, Iran , Shamsizadeh, A Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran
Abstract :
Memantine as N-Methyl-D-Aspartic Acid (NMDA) receptor antagonist is
used in some neurological disorders. Moreover, memantine presents modulatory effects on the
somatosensory information processing in healthy subjects. This study investigated the effects
of memantine on electrophysiological properties of barrel cortex neurons in male rats.
Methods: Single unit recording was used to evaluate the electrophysiological properties of
barrel cortex neurons. The neural responses to the Principal Whisker (PW), Adjacent Whisker
(AW), and combined displacement of two whiskers [20 ms Inter-Stimulus Intervals (ISIs)]
were recorded before and 2 hours after memantine gavage (10 mg/kg). A Condition Test Ratio
(CTR) was calculated for assessing inhibitory interactions.
Results: Two hours after memantine gavage, neuronal ON and OFF responses to PW
deflection were decreased. Furthermore, CTR for both ON and OFF responses was decreased
following memantine administration.
Conclusion: The current study demonstrated that memantine modified neural response
properties in the rat barrel cortex
Keywords :
Rat , Electrophysiology , Somatosensory cortex , Memantine
