The Expression Level of CCDC26 and FOXCUT Genes in Acute Lymphoblastic Leukemia

Background and aim: acute lymphoblastic leukemia (all) is a malignant disease of lymphoid progenitor cells affecting both children and adults. long non-coding rnas (lncrnas) are one kind of non-coding rnas (ncrnas), reported modulating the initiation or progression of diverse cancers. however, the role of ccdc26 and foxcut long non-coding rnas in all has been unknown. in this study, we explored the expression of foxcut and ccdc26 lncrnas in acute lymphoblastic leukemia cell lines. methods: acute t lymphoblastic leukemia cell lines, rpmi 8402, jurkat, b lymphoblastic leukemia, daudi, and ramos cell lines were used. after culturing the cells, rna extraction and cdna synthesis were performed. the real-time pcr technique was then used to study the expression of ccdc26, foxcut, c-kit, and foxc1 genes. result: we found a significant increase of ccdc26 expression in rpmi 8402 (p <0.0001) and ramos (p <0.05) cell lines compared to the control, while decreased expression of these genes was observed in jurkat and daudi cell lines. furthermore, foxcut gene had a significant increase in expression in all cell lines compared to the control (p <0.01 in daudi and rpmi 8402 cell lines) (p <0.001 in jurkat and ramos cell lines). conclusion: our results demonstrated that ccdc26 and foxcut genes can play a regulatory role in acute lymphoblastic leukemia and may serve as a potential diagnostic biomarker and therapeutic target of acute lymphoblastic leukemia.