Author/Authors :
Puti, Erny Division of Nephrology - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Rasyid, Haerani Division of Nephrology - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Tandean, Pendrik Division of Cardiology - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Sanusi, Himawan Division of Endocrine Metabolic and Diabetes - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Kasim, Hasyim Division of Nephrology - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Bakri, Syakib Division of Nephrology - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Aman, Makbul Division of Endocrine Metabolic and Diabetes - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia , Seweng, Arifin Biostatistics Department - Faculty of Public Health - Hasanuddin University, Makassar, South Sulawesi, Indonesia
Abstract :
Background: Both clinical and experimental evidence have been published over the past
few decades supporting the existence of a close relationship between the elevated levels of
serum uric acid with cardiovascular events and acute kidney injury (AKI). This study aimed
to determine the effect of serum uric acid levels on the incidence of AKI in acute coronary
syndrome (ACS) patients.
Methods: A retrospective cohort study with a cross sectional design was performed. The
research was conducted at Dr. Wahidin Sudirohusodo Hospital from October 2019 to
December 2019. Nonrandom sampling was employed in the medical records. All patients
who met the inclusion criteria were at > 18 years old and diagnosed with ACS with AKI.
The demographic data of age, sex and serum uric acid levels were recorded. The data
obtained were analyzed using the SPSS (Statistical Package for Social Sciences).
Results: There were 158 subjects of ACS patients with AKI and 135 without AKI. There
was a significant correlation between high uric acid levels with the incidence of AKI in ACS
(p<0.001). Patients with high serum uric acid levels were 9.5 times at risk of developing
AKI compared to those with normal serum uric acid levels.
Conclusion: High uric acid level is one of the risk factors for AKI in ACS and indicates 9.5
times at risk of developing AKI compared to normal serum uric acid level. Therefore, it is
necessary to monitor serum uric acid level and kidney function in ACS patients.
