Author/Authors :
ABDEL MAKSOUD, Yehia Hamed Pediatric department - Benha University - Benha, Egypt , SULIMAN, Hany Abdelaziz Pediatric department - Benha University - Benha, Egypt , ElSAYED ABDULSAMEA, Sameh Pediatric department - Benha University - Benha, Egypt , MOHAMED KAMAL, Naglaa Pediatric department - Faculty of medicine - Cairo University - Cairo, Egypt , AL-SHOKRAY, Ashraf Hamed Pediatric department - Benha University - Benha, Egypt , IBRAHIM, Asmaa Obada Pediatric department - Ain shams University - Cairo, Egypt , ELSHORBAGY, Hatem Hamed Pediatric Department - Faculty of Medicine - Menoufia University - Shebeen Elkom, Egypt , El Din FATHALLAH, Mohamed Gamal Pediatric department - Faculty of medicine - Cairo University - Cairo, Egypt , ATTIA, Ahmed Mahmoud Pediatric department- Qualiob General Hospital - Qaliob, Egypt , ELSADEK, Akram Elshafey Pediatric department - Benha University - Benha, Egypt
Abstract :
We aimed to investigate the risk factors predicting the development
of intractable epilepsy in children with cerebral palsy (CP), with an
emphasis on perinatal characteristics, seizure semiology, imaging,
and EEG findings.
Materials & Methods
Following a descriptive, retrospective, case-control design, 106
children with CP and epilepsy from 2015 to 2020 were studied
(46 children with CP and intractable epilepsy and 60 with CP and
controlled epilepsy). Data were retrieved from medical records of
participants (i.e., demographics, clinical characteristics, perinatal
history, etiology of seizure and CP, seizure semiology, intellectual
functions, therapeutic options, brain imaging, and EEG findings).
Results
We established a model of the most important risk factors that can
predict intractable epilepsy in children with CP. The model included
the additive effect of a poor Apgar score at 5 minutes, the presence
of neonatal seizures, focal epilepsy, and focal slowing on the EEG
background (Area under the receiver operating characteristic of 0.810).
Conclusion
The findings can be used to identify intractable epilepsy in children
who suffer from CP with further support by offering early therapeutic
interventions intended to reduce the burden of refractory seizures.
Keywords :
Children , Cerebral palsy , Intractable epilepsy , Risk factors
