Author/Authors :
Jiménez-Gastélum, German Reynaldo Facultad de Biología - Universidad Autónoma de Sinaloa, UAS , Espinoza-Ortega, Arely Montserrat Hospital General de Culiacán - “Bernardo J Gastélum” - Servicios de Salud de Sinaloa - Culiacán - Sinaloa, México , Ramos- Payán, Rosalío Facultad de Ciencias Químico Biológicas, UAS , Aguilar-Medina, Maribel Facultad de Ciencias Químico Biológicas, UAS , López-Gutiérrez, Jorge Facultad de Biología - Universidad Autónoma de Sinaloa, UAS , Villegas-Mercado, Carlos Facultad de Odontología, UAS , Ochoa-Ramírez, Luis Antonio Hospital General de Culiacán - “Bernardo J Gastélum” - Servicios de Salud de Sinaloa - Culiacán - Sinaloa, México , Rendón-Aguilar, Horacio Hospital General de Culiacán - “Bernardo J Gastélum” - Servicios de Salud de Sinaloa - Culiacán - Sinaloa, México , Osuna-Ramos, Juan Fidel Departamento de Infectómica y Patogénesis Molecular - Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN) - Ciudad de México, México , Ríos-Tostado, Juan José Hospital General de Culiacán - “Bernardo J Gastélum” - Servicios de Salud de Sinaloa - Culiacán - Sinaloa, México , Velarde-Félix, Jesús Salvador Hospital General de Culiacán - “Bernardo J Gastélum” - Servicios de Salud de Sinaloa - Culiacán - Sinaloa, México
Abstract :
According to the World Health Organization, Mexico
presents one of the highest mortality rates due to coronavirus
disease 2019 (COVID-19). The "cytokine storm" phenomenon has
been proposed as a pathological hallmark of severe COVID-19.
Objective: To determine the association of serum cytokine levels
with COVID-19 severity.
Methods: We studied the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α,
and the IFN-γ serum levels through flow cytometry in 56 COVID-19
patients (24 critical and 32 non-critical) from Northwest Mexico.
Results: We observed a significant increase inthe IL-6 and the IL-
10 levels in the sera of critical patients. These cytokines were also
associated with mechanical ventilation necessity and death, IL-6
showing AUC values above 0.7 for both variables; and correlated
with Na+, creatinine, and platelet levels. On the other hand, no
association was found between IL-2, IL-4, TNF-α, and IFN-γ with
tested variables.
Conclusion: Our results corroborate previous observations
regarding IL-6 and IL-10 involvement in the severity of COVID-19
Keywords :
Mechanic ventilation , IL-10 , Cytokine , COVID-19 , IL-6
