Author/Authors :
Mostafa Gharabaghi, Parvin Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Bakhshandeh Saraskanrood, Masumeh Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Sayyahmelli, Manizheh Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Jafari, Mehri Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Saheb Olad Madarek, Elahe Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Vaezi, Maryam Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Rahmani, Vahideh Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Adili, Ali Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Ebrahimpour, Malahat Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Amidfar, Atie Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran , Pourbargi, Maryam Women’s Reproductive Health Research Center - Department of Obstetrics and Gynecology - Faculty of Medicine - Tabriz University of Medical Sciences, Tabriz, Iran
Abstract :
Objectives: In this study, radical hysterectomy, followed by neoadjuvant chemotherapy (NACT) in patients with locally advanced cervical cancer (LACC) was compared with radical hysterectomy in patients with early-stage cervical cancer.
Material and Methods: This retrospective comparative observational study was performed on 13 patients with LACC International Federation of Gynecology and Obstetrics (FIGO) stage IB2-IIB who underwent a radical hysterectomy after NACT between March 2014 and November 2018. This group was compared with 18 patients undergoing radical hysterectomy with cervical cancer FIGO stage IIA-IB1 in the same period of time.
Results: In the NACT group, 8 (61.5%) and 5 (38.4%) patients were in stages IIB and IB2, respectively, and 13 (72.2%) cases were in the IB1 stage in the non-NACT group. Post-operative blood transfusion in the NACT group was significantly higher compared to the non-NACT group [5 (38.4%) patients versus 0, P = 0.008]. The estimated blood loss (EBL) and operative time were similar between the groups. Finally, there were no significant differences in terms of intra-operative and other post-operative complications.
Conclusions: Radical hysterectomy after NACT in women with LACC seems to be safe and reduces the need for radiation in patients with NACT who are at stage IIB. These results need to be confirmed in studies with a larger patient sample.
Keywords :
Abdominal radical hysterectomy , Cervical cancer , Neoadjuvant chemotherapy , Complications
