Title of article :
Design and Evaluation an Origanum majorana-Capped AgNPs Sensor: Determination of Trace Megestrol Drug in Urine and Blood Samples using Kinetic Spectrophotometric Method
Author/Authors :
Kazemi, Zahra Department of Chemistry - Islamic Azad University Omidiyeh Branch, Omidiyeh , Marahel, Farzaneh Department of Chemistry - Islamic Azad University Omidiyeh Branch, Omidiyeh , Hamoule, Touba Department of Chemistry - Islamic Azad University Omidiyeh Branch, Omidiyeh , Mombeni Goodajdar, Bijan Department of Chemistry - Islamic Azad University Omidiyeh Branch, Omidiyeh
Abstract :
Megestrol drug is a synthetic steroid progesterone, and it is used as an anti-plasma agent to treat
advanced breast cancer or endometriosis. In this study, for determination of megestrol drug in
solution using kinetic spectrophotometric method, we prepared a solution of Origanum majoranacapped
AgNPs utilizing sodium borohydride as a stabilizer sensor. The calibration curve was linear
in the range of (0.01 to 10.0 μg L−1). The standard deviation of (1.8%), and detection limit of the
method (0.023 μg L−1 in time 8 min, 345 nm) were obtained for Sensor level response Origanum
majorana-capped AgNPs with (95%) confidence evaluated. The observed outcomes confirmed the
suitability recovery and a very low detection limit for measuring the megestrol drug. The method
introduced to measure megestrol drug in real samples such as urine and blood was used and can be
used for other drugs and hospital samples.
Keywords :
Megestrol Drug , Origanum majorana-capped AgNPs , Sensor , Measurement , Kinetic
Journal title :
Quarterly Journal of Applied Chemical Research (JACR)
