Title of article :
Evaluation of the Probable linkage between Cytomegalovirus and Type 2 diabetes
Author/Authors :
Azadan, Negin Department of Microbiology - Islamic Azad University Shahr-e-Qods Branch, Tehran , Ferdousi, Atousa Department of Microbiology - Islamic Azad University Shahr-e-Qods Branch, Tehran , Shahhosseini, Mohammad Hasan Department of Microbiology - Islamic Azad University Shahr-e-Qods Branch, Tehran
Abstract :
Some recent investigations, have suggested a probable linkage between
cytomegalovirus (CMV) and developing diabetes. But still there is not enough
literature to assess the rate of this association. To this purpose, in the present study
for detecting CMV genome, serum samples of 50 type 2 diabetic patients as the test
group with an optimized PCR were tested. Sex, age and A1C parameter related to
this group were recorded too. The specificity of the PCR test was 100% and its
sensitivity was 100 copy of the viral genome in the sample. The related results were
compared with the control group that was included 50 non-diabetic participants.
The CMV genome did not find in None of these 100 samples. No related effects
were observed between sex or amount of A1C and association of CMV genome in
these patients. However, it seems that the age parameter is effective in this regard.
Comparing these participants with some other similar research suggest that this
association rate is not very high and the virus only in elderly age can be considered
as a probable risk factor. Thus, for managing diabetes should be more concentrated
on the well-known factors such as obesity or unhealthy lifestyle.
Keywords :
Cytomegalovirus (CMV) , Type2 Diabetes (T2D) , Polymerase chain reaction (PCR)
Journal title :
International Journal of Molecular and Clinical Microbiology (IJMCM)