Title of article
Catalyst free synthesis of indole derivatives via multicomponent reaction of aniline under solvent-free conditions
Author/Authors
Ghasemian Dazmiri, Mahboubeh Department of Chemistry - Faculty of Sciences - Babolsar University, Mazandaran , Ghasemi, Narges National Petrochemical Company (NPC) - petrochemical Research and Technology Company - Arak Center, Arak , Noushin, Annataj Department of Chemistry - Islamic Azad University Gorgan Branch, Gorgan
Pages
5
From page
3031
To page
3035
Abstract
Protonation of the highly reactive 1:1 intermediates produced in the reaction between alkyl(aryl) isocyanides and dibenzoylacetylene by isatin, leads to vinylnitrilium cations, which undergo carbon-centered Michael type addition with the conjugate base of the NH-acid to produce highly functionalized indole-2,3-diones.
Keywords
Activated acetylenic compounds , Aniline , Alkyl(aryl) isocyanides
Journal title
Iranian Journal of Organic Chemistry
Serial Year
2021
Record number
2703331
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