A Simple and one-pot synthesis of highly functionalized piperidines in the presence of an organoacid catalyst under mild conditions

Synthesis of piperidine derivatives by multicomponent reaction between aromatic aldehydes, aromatic amines, and β-ketoesters in the presence of lactic acid (2-hydroxy propanoic acid), as an efficient catalyst in MeOH at 45°C temperature is described. This one-pot methodology offers several advantages such as the use of an inexpensive catalyst, easy access, nonhazardous catalyst, clean work-up, excellent yields, short reaction time, and environmentally mild conditions. In this work was reported the multicomponent (MCRs) synthesis of functionalized tetrahydropyridines with potential biological activity using inexpensive and commercially available material in a one-pot reaction.