Title of article :
Synthesis of pyrimidine derivatives through the reaction of acetylenic compounds in the presence of amides
Author/Authors :
Rostami-Charati, Faramarz Research Center for Conservation of Culture Relics (RCCCR) - Research institute of Cultural Heritage & Tourism, Tehran , Akbari, Reza Department of Chemistry - Facualty of Science - Gonbad Kavous University,Gonbad
Abstract :
The reaction of phthalaldehyde and ammonium acetate, DMAD, and amides 4 in the presence of Et3N at room temperature produce pyrimidine derivatives 5 in excellent yields. High atom economy and yield, mild and clean reaction condition, free catalyst, and short reaction time are some advantages of this procedure for synthesis of pyrimidines.
Keywords :
Four-component reactions , Amide , Isoquinoline , Acetylenic ester
Journal title :
Iranian Journal of Organic Chemistry
