Author/Authors :
Özkan, Tülin Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Altınok, Buket Ankara Üniversitesi - Sağlık Hizmetleri Meslek Yüksekokulu, Turkey , Karadağ, Aynur Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Karabay, Arzu Zeynep Ankara Üniversitesi - Eczacılık Fakültesi - Biyokimya Anabilim Dalı, Turkey , Hekmatshoar, Yalda Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Sayınalp, Nilgün Hacettepe Üniversitesi - İç Hastalıkları Anabilim Dalı Hematoloji Bilim Dalı, Turkey , Sunguroğlu, Asuman Ankara Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey
Abstract :
Acute myeloid leukemia is a type of clonal hematopoietic stem cell disorder displaying different genetic abnormalities. The critical balance between the self-renewal and differentiation of leukemia stem cells are regulated by various genes and signaling pathways that are regulated by these genes. Wnt/ β-catenin signaling pathway controls the self-renewal of hematopoietic stem cells by the regulation of β-catenin. Akirin-2 is an evolutionarily conserved nuclear protein which is thought to play important roles in immunity, NFκB and Wnt/β-catenin signaling pathways. In this study, expression of Akirin-2 gene was investigated in the CD34+ hematopoietic stem cells of patients with high β-catenin gene expression. Our results showed that the expression level of Akirin-2 gene was significantly higher in CD34+ hematopoietic stem cells of patients compared to healthy subjects and Akirin-2 gene could have an important role in AML pathogenesis.
Keywords :
AML , Akirin2 , β , catenin
