L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri

It is an effective antioxidant molecule that exhibits free radical scavenging activity and it enhances antioxidant status in rats and exhibited anticancer properties. It has been shown that α-Lipoic acid is a very effective molecule against type 2 diabetes, atherosclerosis, inflammatory skin diseases, reperfusion arrhythmias and Parkinson’s disease and serves apoptotic action in different cancer cells. These molecules can display important roles in treatment of colon cancer. In this study, we examined the synergetic effects of α-lipoic acid and L-carnitine on HCT 116 +/+ and HCT 116 -/- colon cancer cell line. For this purpose, HCT 116 +/+ and -/- colon cancer cells were treated with L-carnitine and α-Lipoic acid for 24 hours and MTT assay and caspase 3 enzyme activity assay was conducted. α -Lipoic acid and L-carnitine alone or in combination decreased cell viability in HCT 116 +/+ and - /- colon cancer cells and exhibited synergetic effect on the cell viability. Further studies must be conducted to find out the mechanism of their effects in cancer therapy.