WNT Sinyal Yolağı ve Kanser

Wnt signaling pathway is critically important in stem cell biology, both in homeostatic maintenance and regeneration of tissues and organs. Aberrant activation of this pathway has been described as a key player in the development of a wide array of tumor types, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are believed to be responsible for disease relapse, as they possess drug-resistance properties. The development of new therapeutic drugs targeting this pathway to promise new hope to eliminate CSCs and achieve cancer eradication. We review the Wnt signaling pathway, the relationship between this pathway and CSC term and recent therapeutic approaches to target this pathway and their clinical applications.