ciprofloxacin assessment via the formation of precipitate reaction product with ammonium metavanadate as a reagent using isnag-fluorimeter

the assessment of ciprofloxacin.hci using continuous flow injection diverging light was investigated.  a moder, simple, rapid, and sensitive approach  has been developed by using an isnag-fluorimeter analyzer for assessing ciprofloxacin.hci pure state as well as pharmaceuticals (tablets); the process was based on the interaction of ciprofloxacin.hci with ammonium metavanadate (v) (amv) as a precipitating agent to yield an ion pair association yellow precipitate rapidly in salt medium. to increase the affectability of the established approach, optimum parameters have been selected. for the instrument response vs ciprofloxacin-hcl concentrations, the scatter plot range and linear dynamic range were 0.0-50 mmol/l. for linear dynamic range, the correlation coefficient (r) was 0.98623, and the percentage linearity (r2 percent) was 97.26%. with a concentration of 10, 35 mmol/l, the percentage linearity for repeatability (n=8) was less than 0.34 percent. the detection limit of gradual dilution for the lowest concentration in the scatter plot range of the calibration curve was 0.221 g/sample. ciprofloxacin-hci in pharmaceutical tablets was effectively estimated using the described approach. the individual t-test with 95 percent confidence (α=0.05) was used to analyze drugs using the usual incremental technique. the results were also compared to those obtained using traditional uv-spectrophotometric techniques at a wavelength of 272 nm. the isnag-fluorimeter analyzer and traditional techniques yielded no significant differences in the results.