crucial biomarkers for early detection of chronic kidney disease; neutrophil gelatinase-associated lipocalin (ngal) and interleukin-6 (il)-6

chronic kidney disease (ckd) is a gradually progressive disease that recently assumed epidemic proportion. recent studies suggested that both neutrophil gelatinase-associated lipocalin (ngal) produced by tubular cells of the kidney and interleukin 6 (il-6) cytokine are involved in the pathogenesis of ckd. however, for this reason, the research aimed to assess whether (ngal) and il-6 could predict the early detection of ckd. serum and urinary ngal and il-6 levels for all healthy and ckd patients were tested via enzyme-linked immunosorbent assay (elisa). the result notably showed that both serum ngal and urinary ngal levels were significantly increased with disease severity. in the other hand, this study reported that serum il-6 and urine il- 6 in patients with ckd were significantly increased compared with the control group. this study suggests that serum and urine of both ngal and il-6 might be a potentially beneficial biomarker for the early diagnosis of ckd. in conclusion, the level of ngal and il-6 is significantly increased in ckd, indicating that ngal and il-6 are good indicators for early detection of ckd.