Author/Authors :
sami, ramin isfahan university of medical sciences - school of medicine - department of internal medicine, isfahan, iran , hajian, mohammad-reza isfahan university of medical sciences - school of medicine - department of internal medicine, isfahan, iran , amra, babak isfahan university of medical sciences - bamdad respiratory and sleep research center - department of internal medicine, pulmonary and sleep ward, isfahan, iran , soltaninejad, forogh isfahan university of medical sciences - school of medicine - department of internal medicine, isfahan, iran , mansourian, marjan isfahan university of medical sciences - pediatric cardiovascular research center, cardiovascular research institute, isfahan, iran , mirfendereski, sam isfahan university of medical sciences - school of medicine - department of radiology, isfahan, iran , sadegh, raheleh isfahan university of medical sciences - school of medicine - department of community and prevention medicine, isfahan, iran , khademi, nilufar isfahan university of medical sciences - school of medicine - department of internal medicine, isfahan, iran , jalali, soheila isfahan university of medical sciences - school of health - department of epidemiology and biostatistics, isfahan, iran , shokri-mashhadi, nafiseh isfahan university of medical sciences - school of nutrition and food sciences - department of clinical nutrition, isfahan, iran
Abstract :
the cumulative rate of death of acute respiratory syndrome coronavirus 2 (sars-cov-2) has necessitated better recognizing the risk factors of the disease and the covid-19- induced mortality. this cross-sectional study aimed to determine the potential risk factors that predict covid-19-related mortality concentrating on the initial recorded laboratory tests. we extracted admission’s medical records of a total of 136 deaths related to covid-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from february 24^th to april 12^th, 2020, in isfahan, iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. we applied the independent sample t test and a chichi square test with spss software to compare the differences between the survivor and non-survivor patients. a p value of less than 0.05 was considered significant. our results showed that greater length of hospitalization (p≤0.001), pre-existing chronic obstructive pulmonary disease (p≤0.001), high pulse rate, hypoxia (p≤0.001), and high computed tomography scan score (p 0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. moreover, high neutrophil/lymphocyte ratio (or, 1.890; 95% ci, 1.074-3.325, p=0.027), increased creatinine levels (or, 15.488; 95% ci, 0.801-299.479, p=0.07), and elevated potassium levels (or, 13.400; 95% ci, 1.084 -165.618, p=0.043) independently predicted in-hospital death related to covid-19 infection. these results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients.
Keywords :
covid , 19 , risk factors , mortality , medical laboratory science
