Author/Authors :
El-Henawee, Magda Department of Pharmaceutical Chemistry - Faculty of Pharmacy - Zagazig University, Giza, Egypt , Saleh, Hanaa Department of Pharmaceutical Chemistry - Faculty of Pharmacy - Zagazig University, Giza, Egypt , Hussien, Emad Mohamed Department of Analytical Chemistry - National Organization for Drug Control and Research (NODCAR), Giza, Egypt , Rashad Derar, Abeer Department of Analytical Chemistry - National Organization for Drug Control and Research (NODCAR), Giza, Egypt
Abstract :
Herein, an eco-friendly and rapid voltammetric method is suggested for
simultaneous assay of Aceclofenac (ACL) and Ezogabine (EZO) in biological fluids.
Aceclofenac (ACL) and Ezogabine (EZO) are co-administrative drugs which are prescribed
for the treatment of epilepsy associated with chronic inflammatory. The voltammetric method
is based on the electrochemical oxidation of ACL and EZO at an edge plane pyrolytic graphite
electrode using differential pulse voltammetry (DPV). Moreover, the electrochemical
oxidation at carbon paste electrode and carbon paste electrodes modified with nanoparticles
have been remarked. A number of crucial parameters which affect the electrochemical process
at the electrode surface have been optimized. The method is linear over the concentration
ranges from 0.2 to 100.0 μM and from 2.0 to 70.0 μM for ACL and EZO, respectively. The
average recovery was found to be 100±2% with satisfactory %RSD (<1.5%) for both
compounds. The method was applied successfully for simultaneous determination of ACL and
EZO in biological samples with satisfactory accuracy and precision.
Keywords :
Aceclofenac , Ezogabine , Voltammetry , Edge plane pyrolytic graphite , Biological fluids
