Preparation of Degeredable Polyprolactone Polymer (PCL)/Magnetic nanocomposite for Drug Delivery Systems Against Anticancer Compounds

Magnetic nanoparticles have been used primarily for medical advances, chemotherapy, and specialized tissue repair for targeted drug delivery. In this research, magnetic iron nanoparticles were first prepared and identified. Then, biodegradable copolymer of polypro-pylene capro-lactone-polyethylene glycol PCL-PEG1000-PCL was synthesized. Doxorubucin nanoparticles were prepared by using copolymer containing magnetic nanoparticles by solvent-evaporation method. VSM, FT-IR, UV-vis, 1H-NMR and SEM were used to determine the structural properties of copolymer nanoparticles. The synthesis of PCL-PEG1000-PCL triple-block copolymer and doxorubicin and iron nanoparticles encapsulation were confirmed by the mentioned characterization methods. The resulting nanoparticles have superparamagnetic properties and the drug encapsulation yield was about 95%. The effect of pH and heat on drug release curve was investigated. The results showed that the copolymer synthesized is suitable for the encapsulation of doxorubicin and iron nanoparticles and can be effective as a carrier of novel nanostructures in the delivery of anticancer drugs. The results showed that due to the properties of magnetic nanoparticles and copolymers they can be used for targeted drug delivery for targeted drug delivery.