Title of article :
Review on Approved and Inprogress COVID-19 Vaccines
Author/Authors :
Farnudiyan-Habibi ، Amir Department of Pharmaceutical Biomaterials - Faculty of Pharmacy, Medical Biomaterials Research Center - Tehran University of Medical Sciences , Mirjani ، Mobina Department of Pharmaceutical Biomaterials - Faculty of Pharmacy, Medical Biomaterials Research Center - Tehran University of Medical Sciences , Montazeri ، Vahideh Department of Clinical Pharmacy - Virtual University of Medical Sciences , Aliebrahimi ، Shima Department of Medical Education - Virtual University of Medical Sciences , Katouzian ، Iman Australasian Nanoscience and Nanotechnology Initiative (ANNI) - Monash University , Abdolhosseini ، Saeed School of Electrical and Computer Engineering, College of Engineering - University of Tehran , Rahmani ، Ali Department of Pharmaceutical Biomaterials - Faculty of Pharmacy, Medical Biomaterials Research Center - Tehran University of Medical Sciences , Keyvani ، Hossein Department of Virology - School of Medicine - Iran University of Medical Sciences , Ostad ، Nasser Department of Toxicology and Pharmacology - Toxicology and Poisoning Research Centre, Faculty of Pharmacy - Tehran University of Medical Sciences , Rad-Malekshahi ، Mazda Department of Pharmaceutical Biomaterials - Faculty of Pharmacy, Medical Biomaterials Research Center - Tehran University of Medical Sciences
Abstract :
The last generation of Coronavirus named COVID-19 is responsible for the recent worldwide outbreak. Concerning the widespread and quick predominance, there is a critical requirement for designing appropriate vaccines to surmount this grave problem. Correspondingly, in this revision, COVID-19 vaccines (which are being developed until March 29th, 2021) are classified into specific and non-specific categories. Specific vaccines comprise Genetic-based Vaccines (mRNA, DNA), Vector-based, Protein/recombinant protein vaccines, Inactivated viruses, Live-attenuated vaccines, and novel strategies including microneedle arrays (MNAs), and nanoparticles vaccines. Moreover, specific vaccines such as BCG, MRR, and a few other vaccines are considered Nonspecific. What is more, according to the significance of Bioinformatic sciences in the cuttingedge vaccine design and rapid outbreak of COVID-19, herein, Bioinformatic principles including Reverse vaccinology, epitopes prediction/selection and, their further applications in the design of vaccines are discussed. Last but not least, safety, challenges, advantages, and future prospects of COVID-19 vaccines are highlighted.
Keywords :
COVID , 19 , Reverse vaccinology , Bioinformatic , Epitope prediction , mRNA vaccine
Journal title :
Iranian Journal of Pharmaceutical Research(IJPR)
Journal title :
Iranian Journal of Pharmaceutical Research(IJPR)
