Title of article :
Successful Treatment of Postneurosurgical Ventriculitis Caused by Extensively Drug-resistant lt;i gt;Acinetobacter baumannii lt;/i gt; in a Child: Case Report
Author/Authors :
Yang ، Rui Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Li ، Fang Pharmacy Management Department - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Mao ، Weiwei Department of Pediatric Neurosurgery - School of Medicine, Xinhua Hospital - Shanghai Jiao Tong University , Wei ، Xin Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Liu ، Xinzhu Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Guo ، Xiaowen Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Luo ، Wentao Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Liu ، Yan Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University , Zhang ، Jian Department of Clinical Pharmacy - School of Medicine, Xinhua Hospital - Shanghai Jiaotong University
Abstract :
Introduction: The incidence of postneurosurgical Acinetobacter baumannii ventriculitis/meningitis, primarily due to drugresistant strains, has increased considerably in recent years. However, limited therapeutic options are available because most antibiotics poorly penetrate the blood-brain barrier, especially in pediatric patients. Case Presentation: A five-year-old boy developed ventriculitis due to extensively drug-resistant A. baumannii (XDRAB) after bilateral frontal external ventricular drainage for spontaneous intraventricular hemorrhage. Theboywassafelyandsuccessfully treated with intraventricular (IVT)/intrathecal (ITH) polymyxin B together with intravenous tigecycline plus cefoperazone/sulbactam. Conclusions: In the present case, postneurosurgical XDRAB ventriculitis was closely associated with intraventricular hemorrhage and the placement of external ventricular drainage. IVT/ITH polymyxin B combined with intravenous tigecycline and cefoperazone sulbactam could be a therapeutic option against XDRAB ventriculitis in children.
Keywords :
Acinetobacter baumannii , Ventriculitis , Pediatrics , Tigecycline , Polymyxin B
Journal title :
Jundishapur Journal of Microbiology (JJM)
Journal title :
Jundishapur Journal of Microbiology (JJM)
