Study of the Protective Effects of Ginger Extracts Against Induced by Carbon Tetrachloride in Rats

The present study was designed to evaluate the possible hepatoprotective and Antioxidant activity of ethanol and aqueous extracts of Zingiber officinale using carbon tetra chloride (Ccl4 )- induced hepatotoxicity in rats. The study was conducted of 42 male rats; the animals were allocated into 6 groups (7 rats in each group) and treated as follow: groupI treated with oral doses of normal saline and saved as a control; groupII treated with 0.5 ml of volume dose oral doses of Ccl4 suspended in olive oil doses of Ccl4 suspended in olive oil (1:1, v/v) 0.5ml at 3 days in week; group III treated with 0.5 ml of volume dose from Ccl4 plus ethanolic extract at concentration 300 mg/kg at the same time; group IV treated 0.5 ml of volume dose from with Ccl4 plus ethanolic extract at concentration 150 mg/kg at the same time ; group V treated with 0.5 ml of volume dose from Ccl4 plus aqueous extract at concentration 300 mg/kg at same time; group VI treated with 0.5 ml of volume dose from Ccl4 plus aqueous extract at concentration 150 mg/kg at the same time; at the end of treatment period (8 weeks), rats were scarified, blood sample obtained for assessment of oxidative stress parameters and antioxidant parameters MDA , GSH and vitamin C. Additionally, serum levels of ALT and AST were evaluated after and before treatment, the result indicated that ethanol extract at concentration 300mg/kg has the ability to a significant decrease (p 0.05) in activities of serum liver enzyme AST, ALT , vitamin C , and MDA level, a significant increase (p 0.05)in GSH level . The results of this study indicate that the two concentrations(150, 300)mg/kg of the ethanolic Zingiber officinale rhizomes extracts gave a good results, even better than aqueous extract.