Title of article :
Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
Author/Authors :
Rajabi ، Hadi Koc University Research Center for Translational Medicine (KUTTAM), School of Medicine - Koc University , Ahmadi ، Mahdi Tuberculosis and Lung Diseases Research Center - Tabriz University of Medical Sciences , Aslani ، Somayeh Department of Biochemistry and Clinical Laboratories - Faculty of Medicine - Tabriz University of Medical Sciences , Saberianpour ، Shirin Vascular and Endovascular Surgery Research Center - Mashhad University of Medical Sciences , Rahbarghazi ، Reza
Abstract :
Type 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further researches have revealed an effective role of exendin-4 in treatment of T2DM related diseases. Exendin-4 is approximately similar to Glucagon-like peptide, thus it can bind to the glucagon-like peptide-1 receptor (GLP-1R) and activated different signaling pathways that are involved in various bioactivities such as apoptosis, insulin secretion and inactivation of microglial. In this review, we investigated the interesting role of exendin-4 in various kinds of T2DM related disorders through the activation of different signaling pathways.
Keywords :
Diabetes complications , Exendin , 4 , Signaling pathways
Journal title :
Advanced Pharmaceutical Bulletin
Journal title :
Advanced Pharmaceutical Bulletin
