Author/Authors :
xia, mengyao shandong university of traditional chinese medicine - school of pharmacy - department of pharmacology, ji’nan, china , zhao, tingting shandong university of traditional chinese medicine - center for foreign language translation, college of foreign languages, ji’nan, china , wang, xiaolong shandong university of traditional chinese medicine - innovation research institute of chinese medicine, ji’nan, china , li, yang shandong university of traditional chinese medicine - college of intelligence and information engineering - department of drug design, ji’nan, china , li, yanling shandong university of traditional chinese medicine - school of pharmacy - department of pharmacology, ji’nan, china , zheng, tingting shandong university of traditional chinese medicine - school of pharmacy - department of pharmacology, ji’nan, china , li, jiaxin shandong university of traditional chinese medicine - school of pharmacy - department of pharmacology, ji’nan, china , feng, yu shandong university of traditional chinese medicine - school of pharmacy - department of pharmacology, ji’nan, china , wei, yongli affiliated hospital of shandong university of traditional chinese medicine, ji’nan, china , sun, peng shandong university of traditional chinese medicine - innovation research institute of chinese medicine, ji’nan, china
Abstract :
brain-derived neurotrophic factor (bdnf) is a protein that performs a neurotrophic function. bdnf and its receptors are widely expressed in the nervous system and can promote the growth of neurons and the formation of neuronal synapses in the brain. studies have shown that a lack of bdnf can lead to impairment of memory and cognitive functions, indicating that bdnf plays an important role in mental illness and neurodegenerative diseases. the combination of stem cells and bdnf-releasing nanomaterials holds great promise in regenerative medicine, especially in the treatment of neurological diseases. for example, alzheimer’s disease, depression, parkinson’s disease, spinal cord injury, etc. the combination of stem cell/pharmacologically active carrier and bdnf-nano/hydrogel provided a useful new type of local delivery tool for the treatment of the nervous system and other diseases. it can not only provide bdnf but also stem cells. these studies will provide a scientific basis for the development and application of bdnf in the future.
Keywords :
brain , derived neurotrophic factor , pathogenesis , nanomaterials , hydrogel , drug delivery , neuropsychiatric diseases
