EFFECT OF ETHANOLIC RED CABBAGE EXTRACT ON OXIDATIVE STRESS IN HYPERTHYROID RABBITS INDUCED BY LTHYROXINE

The protective effect of red cabbage extracts against hyperthyroid induced by Lthyroxine in male rabbits was studied. Forty animals were divided randomly into four groups. Group A: Healthy rabbits, Group B: Healthy rabbits received (100 mg/kg.b.w) red cabbage extract, Group C: hyperthyroid rabbits were given an oral dose of (20μg/kg b.w) L-thyroxine once daily for four weeks to induce hyperthyroidism and group D: hyperthyroid rabbits received red cabbage extract. At the end of the experiment, blood samples were taken for biochemical analysis. The obtained results revealed that hyperthyroid rabbits induced by L-thyroxine had significant increase(P 0.01) in serum levels of triodothyronine (T3), Thyroxine (T4), lipid peroxidation marker malondialdehyde (MDA), as well as significant decrease in reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT) enzymes, compared to the normal control group. Oral administration red cabbage extract caused significant reduction in serum levels of T3, T4 as well as MDA and produced significant increase in thyroid stimulating hormone (TSH), GSH, GPX, SOD and CAT, compared to the positive group. Red cabbage treatment suppresses the hyperthyroidism-induced oxidative damage. These results suggest that experimental hyperthyroidism is accompanied with increased oxidative stress and with the consumption of antioxidant enzymes in induced oxidative aggressions. A protective effect of red cabbage extract on oxidative stress induced by excessive administration of thyroid hormones were detected and for the first time anti hyperthyroid activity was observed.