Author/Authors :
Zandi, Milad Department of Virology - School of Public Health - Tehran University of Medical Sciences , Fazeli, Maryam Department of Medical Virology - Faculty of Medicine - Hamadan University of Medical Sciences , Ghadimi, Parnian Faculty of Medicine - Guilan University of Medical Sciences , Soltani, Saber Department of Virology - School of Public Health - Tehran University of Medical Sciences , Azizi Jalilian, Farid Department of Medical Virology - Faculty of Medicine - Hamadan University of Medical Sciences , Banai Shahani, Aryan Scientific Research Center - Tehran University of Medical Sciences , Behboudi, Emad Department of Microbiology - Faculty of Medicine - Golestan University of Medical Sciences , Pourhossein, Behzad Department of Medical Virology - Faculty of Medicine - Hamadan University of Medical Sciences
Abstract :
Autophagy is a conserved lysosomal degradation pathway that breaks down cytoplasmic components and is essential for host cellular immune response. The activity of autophagy at a basic rate is crucial for homeostasis. Autophagy has emerged in recent years as a major mechanism in many neurodegenerative diseases. The regulation of microbial infections and inflammatory responses can be significantly influenced by autophagic modulators. In this study, we explain the autophagy role as a double-edged sword in anesthesiology and critical care. Future studies should focus on investigating the molecular mechanism of interplay between pathogen-host-autophagy and on studying whether autophagy inducers/inhibitors can exert suitable modulatory immunomodulatory effects. Potential organ protection through autophagy pathways might be an advantage in patients undergoing anesthesia and/or needing critical care.
