Phytochemical Screening and the Effect of Methanolic Leaves Extract of Senna mimosoides on Inflammatory Stimulus-Induced Leukocyte Mobilization (In-vivo)

In traditional medicine, the leaves of Senna mimosoides, has been used to cure oedema and breastfeeding poisoning in newborns. The animal model experiment included a total of twenty-􀀻ive (25) Wistar albino rats of both sexes, with A (control) receiving 0.2 ml of normal saline. B, C and D received 100, 250 and 500 mg/kg of the methanolic extract respectively, and E receiving 25 mk/kg of the indomethacin standard drug. Preliminary phytochemical screening of the Senna mimisoides methanolic leaves extract indicated the presence of ten (10) different secondary metabolites, including; carbohydrates, glycosides, tannins, reducing sugars, phenols, steroids, terpenoids, saponins, alkaloids and flavonoids. When compared to the control, the total leukocyte count of the groups treated with various dosages of extracts increased in a dose-dependent manner, whereas the group treated with indomethacin fell dramatically. The extract dramatically increased leukocyte mobilization, according to the findings. The results of this investigation showed that the methanolic leaves extract of Senna mimosoides contains medically relevant bioactive components, indicating that it can be used in traditional medicine to treat ailments. The anti-inflammatory property of the extract is not at the level of leuckocyte mobilization. According to this study, however, the extract’s ability to stimulate leukocytes implies that it may have a function in immunological response.