Comparative Studies on Anti-hyperglycemic Effects of Ethyl Acetate and Methanol Extract of Albizzia lucida Benth Bark in Alloxan Induced Diabetic Rats

The decoction of the bark of Albizzia lucida Benth was used in ayurvedic system for management of diabetes mellitus. To confirm the traditional claim, the comparative anti-hyperglycemic efficiency of ethyl acetate extract of bark of Albizzia lucida Benth. (EEAL) and methanol extract of bark of Albizzia lucida Benth. (MEAL) was done in alloxan induced diabetic rats. Acute and sub-acute effect of oral administration of EEAL and MEAL (200 400 mg/kg, b.wt) on blood glucose was observed in different time interval for 10 days. By the end of the study, the collected blood sample and pancreas was used for estimation of serum lipid profile and histological studies. EEAL and MEAL showed that the serum blood glucose and serum lipids (total cholesterol, triglyceride, VLDL-cholesterol, LDL-cholesterol) was reduced significantly (p 0.01) in dose dependent manner when compare to control group. At the same time MEAL was showed potent effect than EEAL. EEAL and MEAL does not affect the body weight and alter the histopathology of pancreas similar to that of normal. It was concluded that EEAL extract of bark of Albizzia lucida Benth and MEAL extract of bark of Albizzia lucida Benth. possess anti-hyperglycemic activity in alloxan-induced diabetic model rats.