Author/Authors :
Jamaati, Hamidreza Chronic Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Tabarsi, Payam Clinical Tuberculosis and Epidemiology Research Center - NRITLD - Shahid Beheshti University of Medical Sciences , Bahrami, Naghmeh Department of Tissue Engineering and Applied Cell Sciences - School of Advanced Technologies in Medicine - Tehran University of Medical Sciences , Yasari, Fatemeh Chronic Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Varahram, Mohammad Mycobacteriology Research Center - NRITLD - Shahid Beheshti University of Medical Sciences , Kazempour Dizaji, Mehdi Biostatistics Department - Mycobacteriology Research Center - National Research Institute of Tuberculosis and Lung Diseases - Masih Daneshvari Hospital - Shahid Beheshti University of Medical Sciences , Mohammad Reza, Hashemian Chronic Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Daustani, Mahya Department of Biotechnology - Faculty of Sciences - Islamic Azad University, Tehran , Emami, Maral Chronic Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Shirian, Sadegh Department of Pathology, School of Veterinary Medicine, Shahrekord University , Masumi, Ladan Shiraz University of Medical Sciences , Rasouli, Amir Department of biochemistry - Ghods city branch - Islamic Azad University , Narimani, Armita Department of Cell and Molecular Biology - School of Biological Sciences - North Tehran Branch - Islamic Azad University, , Ahmadian, Nasser Transplantation Center - Department of Curative Affairs - Ministry of Health and Medical Education , Mohamadnia, Abdolreza Chronic Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Velayati, Ali Akbar Mycobacteriology Research Center - NRITLD - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Coronavirus has become a global concern in 2019-20. The virus belongs to the coronavirus family, which has been able to infect many patients and victims around the world. The virus originated in the Chinese city of Wuhan, which eventually spread around the world and became a pandemic.
Materials and Methods: A total of 60 Patients with severe (n=30) and mild (n=30) symptoms of COIVD-19 were included in this study. Peripheral blood samples were collected from the patients. Real-time PCR was used to compare the relative expression levels of Procalcitonin and dipeptidyl peptidase IV (DPPIV) in a patient with severe and mild Covid-19 infection.
Results: Procalcitonin and dipeptidyl peptidase IV markers in the peripheral blood of patients with severe symptoms, were positive in 29 (96.60%) and 26 (86.60%), respectively (n=30); however, positive rates in the mild symptoms patients group were 27 (90%) and 25 (83.30%), respectively. There was a statistically significant difference between these two groups in terms of DDPIV and Procalcitonin (p<0.001).
Conclusion: Procalcitonin and DPPIV increase in patients with COVID-19 infection, significantly higher in the patients with more severe clinical symptoms than those with milder ones. More studies will be needed to verify the reliability of the current findings.
Keywords :
Procalcitonin , DPPIV , Severe symptoms , Mild symptoms , COVID-19
